Protein & Peptides

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PEG-MGF

PEG-MGF

$40.00
Tax excluded

PEG-MGF 2mg Vial

What is the Pegylation of Mechano Growth Factor? PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the bloodstream without being broken down. Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.

When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. In a rodent study, a single intramuscular injection into muscle resulted in a 25% increase in mean muscle fibre cross-section area within three weeks. Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase. It would also appear that with regards to age, the young have a better ability to respond to MGF, and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.

Description:
2.7 kDa peptide containing 24 amino acid residues.

PEG-H-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2

Synonyms:

PEG-MGF, Pegylated Mechano Growth Factor, Pegylated Somatomedin-C splice variant.

Physical Appearance:
Sterile Filtered White lyophilized (freeze-dried) powder.

Specificity:

Mechano growth factor has an affinity to growth factor receptors in myocytes.

Purity:
>99.8% (HPLC analyzed).

Solubility:
Add 1 ml of sterile diluent and let the lyophilized pellet dissolve completely.

Stability:
Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.

Source:
Biosynthesis

Usage: 
The Product is prepared for 
LABORATORY RESEARCH USE ONLY. The product may not be used for other purposes.

PEG-MGF

Specific References

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