Protein & Peptides
PEG-MGF 2mg Vial
What is the Pegylation of Mechano Growth Factor? PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the bloodstream without being broken down. Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.
When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. In a rodent study, a single intramuscular injection into muscle resulted in a 25% increase in mean muscle fibre cross-section area within three weeks. Using a similar protocol, liver-derived IGF-1 took four months to produce a 15% increase. It would also appear that with regards to age, the young have a better ability to respond to MGF, and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.